Recent research reveals that regular consumption of orange juice significantly influences gene activity in immune cells, affecting thousands of genes involved in blood pressure regulation, inflammation reduction, and sugar metabolism. A study where adults drank 500 ml daily for two months showed decreased activity in inflammation-related genes such as NAMPT, IL6, IL1B, and NLRP3, and lower activity in the SGK1 gene, which impacts sodium retention by the kidneys. These genetic changes are associated with lower blood pressure and reduced inflammation, contributing to long-term cardiovascular health. The antioxidant hesperidin in oranges plays a key role in these benefits, promoting blood vessel relaxation and cholesterol balance. Body type influences response: overweight individuals show more changes in fat metabolism genes, while leaner individuals experience stronger anti-inflammatory effects. Additional studies indicate that orange juice can reduce insulin resistance and LDL cholesterol, with some evidence of improved endothelial function and increased levels of HDL cholesterol. Metabolite analyses suggest orange juice enhances energy utilization, intercellular communication, and inflammatory pathways, with beneficial effects on gut bacteria linked to healthy blood pressure. Globally, the orange juice market is expanding, especially in Saudi Arabia, driven by health awareness, technological innovations, and market shifts aligned with national health policies. The industry is adopting automation, sustainable practices, and organic labeling to meet consumer demands. Overall, orange juice is evolving from a simple beverage to a functional food with proven health benefits, supported by scientific research, cultural significance, and market growth, making it a key player in health and nutrition in 2025.