On February 21, 2026, the No. 16 St. John's Red Storm (21-5, 14-1 Big East) hosts the Creighton Bluejays (14-13, 8-8 Big East) at Madison Square Garden in New York, with tip-off scheduled for noon ET on FOX. St. John's is favored by 12.5 points with an over/under of 155.5. The teams previously met on January 10, with St. John's winning 90-73 in Omaha. St. John's has won 12 consecutive games, including a 76-70 victory over Marquette last Wednesday, but has shown inconsistency against the spread recently, going 1-2 ATS in the last three games. Creighton upset No. 5 UConn 91-84 on Wednesday as a 15.5-point underdog, ending a two-game losing streak and a 0-10 ATS run in recent games. According to betting odds, St. John's is a heavy favorite with -900 moneyline odds, while Creighton is a significant underdog at +575. The spread favors St. John's at -12.5, with the over/under set at 153.5. Predictions favor St. John's to win 82-73, with betting recommendations including a play on Creighton +12.5 and the over 153.5, although the moneyline bet on St. John's is considered high risk and not advisable. Key player stats show St. John's leading scorers like Zuby Ejiofor and Bryce Hopkins, while Creighton's top performers include Josh Dix and Austin Swartz. The teams' recent results and statistical comparisons indicate St. John's has a more potent offense, but Creighton can be competitive, especially with recent upset wins.